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產品英文名稱：StemRD W3A-H-025 WNT-3a,human,25ug
產品中文名稱：StemRD W3A-H-025人源WNT-3a 蛋白因子，25ug
產品信息
Wnt糖蛋白是存在于多種生物體內的一種細胞外配體，Wnt作為形態(tài)發(fā)生素通過激發(fā)細胞內遠離信號發(fā)送區(qū)域的濃度依賴反應控制胚胎形態(tài)發(fā)育。Wnt通路調節(jié)動物發(fā)育過程中的多個重要環(huán)節(jié)，例如細胞增殖、細胞遷徙及細胞分化。Wnt蛋白通過自分泌或旁分泌作用與位于細胞膜上的受體相結合，激活細胞內信號通路調節(jié)靶基因的表達，對細胞的增殖、分化、遷移、極性化和凋亡起到重要作用。
StemRD W3A-H-025B WNT-3a,human,25ug 產品簡介
StemRD已研發(fā)出一種新穎的表達和純化諸如StemRD W3A-H-025B WNT-3a,human,25ug 蛋白等“困難"蛋白的*方法。我們*的處理方法能得到純度和活性均于市場方法生產的WNT蛋白。StemRD W3A-H-025B WNT-3a,human,25ug 蛋白絕不含有現今市場普遍使用的WNT蛋白中含有的某些非特異性成分。
WNT-3a 干細胞生長分化因子是WNT 信號蛋白家庭的成員之一，在胚胎成長和成體組織維護方面起關鍵作用。WNT-3a 干細胞生長分化因子是典型的通過β-聯蛋白通路發(fā)送信號。已有規(guī)格的WNT-3a是一個包含328個氨基酸殘基的單鏈蛋白質。由于糖基化，WNT-3a 在非還原條件下用SDS-PAGE處理會明顯損失掉38-41 kDa分子量。StemRD公司生產的WNT-3a干細胞生長分化因子是用人體細胞系中Wnt-3a cDNA 在無蛋白培養(yǎng)基上過度表達得到。使用StemRD W3A-H-025B WNT-3a,human,25ug *的純化方法，區(qū)別于其它已發(fā)表的純化方法，提高蛋白純度。
StemRD W3A-H-025B人源WNT-3a 蛋白因子，25ug 產品特性
?StemRD W3A-H-025B人源WNT-3a 蛋白因子，25ug 干細胞生長分化因子使用LC/MS 層析，純度大于98%，結構經過NMR驗證
?StemRD W3A-H-025B人源WNT-3a 蛋白因子，25ug 干細胞生長分化因子生物活性認證：經過生物試驗驗證，優(yōu)于其它同類型產品
? WNT-3a 干細胞生長分化因子是典型的通過β-聯蛋白通路發(fā)送信號
StemRD W3A-H-025B人源WNT-3a 蛋白因子，25ug 保存方法
The lyophilized protein is stable for at least 6 months if stored at -80 degreeC. Reconstituted protein is stable for at least two weeks at 4 degree C, but should be stored in aliquots at -80 degree C for longer term. Avoid repeated freeze and thaw.
StemRD W3A-H-025B WNT-3a,human,25ug 產品英文描述
We express and purify StemRD W3A-H-025B WNT-3a,human,25ug proteins by using a proprietary process that is distinctive from the published protocol. Our method results inStemRD W3A-H-025B WNT-3a,human,25ug proteins that are purer and more active than market-leading products which have been associated with non-specific artifacts.
WNT-3a is a member of the WNT family of signaling proteins that play key roles in embryonic development and the maintenance of adult tissues. WNT-3a is a prototypic canonical WNT that signals through the β-catenin pathway. The predicted size of human WNT-3a is a monomeric protein containing 328 amino acid residues. Due to glycosylation, it migrates at an apparent molecular weight of 38 - 41 kDa on SDS-PAGE under non-reducing conditions. StemRD’s W3A-H-025B WNT-3a,human,25ug,is produced from a human cell line overexpressing human Wnt-3a cDNA in protein-free medium.Purification is done by a proprietary process that is distinct from the published method.
WNT all compounds are:
1. >98% pure by LC/MS analysis, and structurally verified by NMR.
2. Bioactivity Certified: tested for biological activities, an advent-age over other supplies.
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